Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.
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Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April The increasing incidence of obesity and the metabolic syndrome over the past two decades hyperuriceima coincided with a marked increase in total fructose intake. Journal List Diabetes Care v.
In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children. Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change.
Although the cumulative fructose load was large 1. After the infusion of fructose, 0. In addition, we observed that a serum uric acid level above 5.
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Published online Aug It has not been assessed, however, whether UA also increases when fructose is administered as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.
This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.
In three patients with induxed, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose. The serum Pi level decreased 2. Am J Clin Nutr ; Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.
As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance.
These effects are generally attributed to an increased UA production, as observed after intravenous fructose administration 2. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar.
F—F [ PubMed ]. Open in a separate window. National Center for Biotechnology InformationU. These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.
These samples were collected while subjects were participating in two clinical trials clinical trial reg. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Nutr Metab Lond ; 9: Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries.
The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were Acknowledgments This study was supported by grant from the Hypeguricemia National Foundation for Science and by a vructose from Ajinomoto Co.
Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1. This effect appears to be specific for fructose. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans
We recently reported that uric acid reduces levels of endothelial nitric oxide NO jyperuricemia, a key mediator of insulin action. Animals deficient in endothelial NO develop insulin resistance and other features of the metabolic syndrome. Closed symbols represent data collected after 4—6 days of HFrD.
The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0. NO increases blood flow to skeletal muscle and enhances glucose uptake.
Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1.