Fisiologia Renal de Vander – Ebook download as PDF File .pdf) or read book online. Conciso e didático, este livro explora os aspectos fundamentais da fisiologia renal que são essenciais para o bom entendimento da medicina clínica. : FISIOLOGIA RENAL DE VANDER 6TA. EDIC. by EATON DOUGLAS C. () by Douglas C. Eaton and a great selection of similar.

Author: Gardarn Nikorisar
Country: Gabon
Language: English (Spanish)
Genre: Technology
Published (Last): 15 April 2008
Pages: 291
PDF File Size: 12.43 Mb
ePub File Size: 12.20 Mb
ISBN: 902-6-94501-226-9
Downloads: 39690
Price: Free* [*Free Regsitration Required]
Uploader: Vikus

It could be hypothesized that the phenomenon of net creatinine tubular reabsorption documented on very old people could be explained due to the senile structural tubular fisiolkgia atrophy, etc. Besides, it has been documented that free water clearance a marker of TALH function is considerably lower in fissiologia very old in comparison with the young: Since furosemide stimulates sodium loss due to the inhibition of its reabsorption at the level of the TALH, the lower increase in soduria after furosemide infusion in the very old in comparison with the young could be explained by the functional reduction in the TALH furosemide blocking site due to the senescence process[ 23 – 25 ].

Furosemide intravenous infusion furosemide test shows that fractional excretion of renzl FENa post-furosemide infusion is significantly lower in the very old group in comparison with the young one: Geriatric nephrology and the ‘nephrogeriatric ifsiologia.

This increase in the urea urinary excretion, as well as the low protein diet that aged people usually have, both explain the normal serum urea value characteristically found in the elderly, despite of their reduced glomerular filtration rate[ 17 ].

In the present review article, we explain in detail the characteristics of the creatinine, urea, uric acid, sodium, water, and potassium renal handling in the very old healthy people taking the younger group years as a parameter.

Feed-back between geriatric syndromes: Aldosterone bioactivity in this segment is studied using the furosemide test, which vanderx generates a discrete hypovolemia that stimulates the vahders of this hormone, which in turn stimulates the secretion of potassium in the collecting tubules.

These finding could be fisioloia as the fact that the dehydration over expresses the habitual senile creatinine back-filtration. The procurement of a ratio between the CC and the CCWC allows for the evaluation of the net tubular handling of this substance: Each chapter is filled with the tools you need to truly learn key concepts rather than merely memorize facts.

Published online Oct 6. Anatomical changes in the aging kidney.

Fisiología renal de Vander – Douglas C. Eaton, John P. Pooler – Google Books

Something similar was documented in the newborns but in this case it was attributed to tubular immaturity since this finding disappeared as they grew older[ 89 ].

Renal physiology in the healthy oldest old has the following characteristics, in comparison with the renal physiology in the young: Fiaiologia 91 99 99 Fax 91 21 Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. As regards the maximum tubular dilution capacity, another of the parameters which Chaimowitz test can evaluate, it has been reported that such dilution is significantly reduced in the very old in comparison with the young: TTKG in basal situation, does not show any significant difference between the very old group and the young one, despite the existence of lower glomerular filtration in the very old, which ultimately accounts for the relatively reduced cation excretion in vanrers very old, since it is known that the potassium excretion tends to increase paralelly to the reduction of glomerular filtration: The observed difference in the creatinine filtration between the studied age groups could be justified as a consequence of the decrease in the number of glomerular units secondary to their obliteration due to the glomeruloscrerosis which accompanies ageing[ 3 – 5 ].


Regarding tubular sodium handling in the oldest old, it has been documented that the selective reabsorption of sodium at the proximal tubule, evaluated using the Chaimowitz test, shows that it remains in the normal range: This has been attributed to the senile medullar hypotonicity[ 324 ].

Abstract Renal physiology in the healthy oldest old has the following characteristics, in comparison vandes the renal physiology in the young: All physiological changes of the aged kidney are the same in both genders.

Renal handling of many substances creatinine, urea, sodium, water, potassium significantly differs between very old healthy people and young one, while there is no change in uric acid renal handling between these groups.

Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old

Clinical consequences[ 13 ]: Renal reserve in the oldest old. On the other hand, serum uric acid level and fractional excretion of uric acid FEUAc do not differ between very old healthy people in comparison with healthy young ones.

Rennke H, Denker B. Creatinine reabsorption by the aged kidney.

Fisiologia Renal de Vander

The lower reabsorption of sodium in TALH is translated into a lower medullar concentration of sodium, which causes senile medullar hypotonicity and as a consequence to a reduction in the urinary concentration capacity, which can be the cause of dehydration in the old in situations of high loss of water or low intake[ 13 ].

Combining the latest research with a fully integrated teaching approach, the eighth edition of Vander’s Renal Physiology features revised sections that explain how the kidneys affect other body systems and how they in turn are affected by these systems. Written in a clear, concise, logical style, this trusted text reviews the fundamental principles of the structure, function and pathologies of the human kidney that are essential for an understanding of clinical medicine.

The previously described physiological alterations also show that the characteristic senile sodium urinary loss depends not only on the reduced sodium reabsorbed in the TALH but also in the collecting tubules[ 24 ].


Studies in old rats have documented a significant reduction in the number of co-transporters NKCC2 in comparison with young ones. To examine these signaling mechanisms, he uses contemporary methods of cellular and molecular biology including patch voltage clamp methods and expression of cloned signaling molecules in Xenopus oocytes and other expression systems.

In this test, it is observed that the basal fractional excretion of potassium FEK before furosemide infusion is not significantly different in the young and the very old group, whereas the highest FEK post-infusion of furosemide is significantly lower in the very old group in comparison with the young one: Support Fisiolgia Support Center.

Additionally, it is important to point out that there are no significant physiological differences related to gender in both age populations.

Fisiologia Renal de Vander – Douglas C. Eaton | John P. Pooler – Google Books

The information obtained by means of the furosemide test senile hyposecretion of potassium explains fisiollogia the tubular handling of potassium measured as FEK and transtubular potassium gradient: Due to the fact that a reduction in the number of urea channels UT1 has been documented in the collecting tubules of very old rats, it could be suggested that the senile increase in urea excretion may be the consequence of a lower reabsorption of urea at the distal tubules[ 17 ].

The aging kidney in health and disease. Even though, the above mentioned creatinine renal filtration difference between the age groups, there is no significant difference regarding their serum creatinine value between them. The goal of his research is to examine the cellular signaling mechanisms which control all aspects of cellular function including cell growth, division, and responses to external stimuli.

National Center for Biotechnology InformationU.

Even nowadays the limits that separate the changes vanfers typical of the normal ageing process of those patients who suffer from high prevalent illnesses characteristic of this period are not clear. Physiology of the healthy ageing kidney.

Renal physiology in the oldest old: Fisiologix and physiological changes of the kidneys including changes in glomerular filtration rate. Additionally, the high urea urinary excretion documented in the very old could be one of the factors which explains the senile medullar hypotonicity reduced urea medullar content and the nocturia urea osmotic diuresis usually found in the very old patients[ 1516 ]. The values of aldosterone post-infusion of furosemide are significantly higher in the very old group in genal with the young: Renal handling of sodium in old people: