DVH 5161 PDF

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Minor clinical symptoms with no medical intervention required were considered grade 1; moderate symptoms requiring pain medication with good response, grade 2; and severe symptoms, treated with multiple pain medications, including neuropathic drugs or steroid injections, with some or no improvement dvg symptoms, grade 3.

The superior border of the plexus was initiated between the neural fvh at C4-C5 where the nerve was traced as it exited the foramina. We developed a computer-assisted image segmentation method which allowed us to rapidly and consistently contour the brachial plexus and establish the dose limits to minimize the risk of brachial plexopathy.

Author information Copyright and License information Disclaimer. The V 10 values volume of brachial plexus volume receiving 10 Gy were To save time and improve the consistency of contouring, we applied a new multi-atlas segmentation method to automatically delineate brachial plexus contours as follows. Significant effect of adjuvant chemotherapy on survival in locally advanced non-small-cell lung carcinoma. Other significant risk factors were having plexopathy before treatment OR 4.

Initial results of the phase II trial RTOG to evaluate the feasibility of dose escalation to 74 Gy with concurrent chemotherapy for unresectable NSCLC were encouraging; the median overall survival time, 24 months, compares favorably to that produced by the lower Gy dose used in RTOG [ 6 ]. It is well known that peripheral nerves are sensitive to recurrent episodes of trauma, whether from tumor invasion or from surgical intervention [ 9dvvh ]; multiple traumas might be expected to reduce the threshold for development of symptoms.

Finally, because brachial plexopathy is relatively rare, the number of events in our study was low, which complicates our ability to generalize our defined dose limits to a larger population of patients with lung cancer.


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P values of 0. These 10 images were then incorporated in the deformable registry program. In this study we found that plexopathy before treatment was also associated with greater risk of toxicity after treatment. The resultant displacement vector fields characterizing the individual registrations were then used to deform the atlas brachial plexus contours to obtain 10 individual segmentations for each patient. C DRR showing patient with a superior sulcus tumor with contours of the brachial plexus generated by deformable image registration followed by manual modification.

Preliminary report by the Radiation Therapy Oncology Group. When patients were treated with proton therapy using Varian Eclipse treatment planning, DICOM-RT dose plans were first exported from Eclipse planning system and then converted and imported into Pinnacle planning system for dose calculation.

Journal of Clinical Oncology. Lung cancer is the leading cause of cancer-related death worldwide, with approximately 1.

Complication without a cure. We used a multi-atlas segmentation method combined with deformable image registration to delineate the brachial plexuson the original planning CT scans and scoredplexopathy according to the Common Terminology Criteria for Adverse Events v4. The planned tumor volume PTV received 74 Gy. The median dose to the tumor was 70 Gy range Bar graphs representing the percent risk for brachial plexopathy according to a cutoff median dose of 69 Gy to the entire brachial plexus panel A and a 75 Gy dose cutoff to 2 cm 3 of the evh plexus panel B.

In this retrospective analysis, we compared dose-volume histogram information with the incidence of plexopathy to establish the maximum tolerated dose to the brachial plexus.

Most studies since have recommended the maximum dose be kept under 66 Gy. Arya AminiB. National Center for Biotechnology InformationU.


For lung cancers near the apical region, brachial plexopathy is a major concern for high-dose radiation therapy. The two curves were nearly superimposable. However, radiation doses of that magnitude often result in local failure, which itself cancause brachial plexopathy. The median maximum doses to 0. Brachial plexus contouring using deformable image registration.

The suggested maximum of 66 Dvvh et al[ 10 ] caused few problems when the definitive dose for lung cancer was 60 Gy. For these reasons, estimates of smaller point doses may not have been accurate enough to predict the development of plexopathy. Development and validation of a standardized method for contouring the brachial evh Even with the differences in anatomy and positioning among patients, we noticed excellent correlation between the STAPLE fused contours and the manually generated contours, suggesting that STAPLE fusion of multiple individual segmentations can reduce variability and produce accurate contours.


Interestingly, we found that doses to 0. The maximum doses to 0.

Radiation-induced brachial plexopathy and hypofractionated regimens in dvu irradiation of patients with breast cancer–a review. Among patients identified as having unresectable NSCLC treated with definitive chemoradiation, ddvh had superior sulcus tumors or tumors involving the upper mediastinum or supraclavicular region and had received a dose of at least 55 Gy to 0. Implementation and validation of a three-dimensional deformable registration algorithm for targeted prostate cancer radiotherapy.

Tolerance of normal tissue to therapeutic irradiation.

Maria Johnson | DVHS JV vs Irvington HS 47 – San Ramon CA | IMG_

This study was approved by the appropriate institutional review board of MD Anderson. The purpose of this study was to identify a threshold radiation dose at which plexopathy becomes evident when that radiation is delivered using modern-day techniques to tumors in the superior sulcus, upper mediastinum, or supraclavicular regions.

J Natl Cancer Inst. There were minimal differences in DVHs between the auto-segmented contours and the modified contours. We identified C5 through T1 roots, which served as the medial borders of the brachial plexus; the plexus was contoured from medial to lateral using the scalene muscles as landmarks[ 11 ].

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Several explanations are possible, including the difficulty of accurately predicting the dose to a very small portion of a structure that is itself quite small in relation to other surrounding organs; tumor motion, change in tumor size, and variations in patient anatomy and positioning during treatment would all be further sources of inaccuracy. Only minor modifications were made mostly as a result of arm position for these 51611.

B Digitally-reconstructed radiographs DRR showing manual contours green and computer-generated contours red.